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For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of mg or decreased to 25 mg. The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by fold see Warnings and Precautions 5.

   
7.3

Sarah (taken for 2 to 5 years) 18.06.2016

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The objectives of this study were to evaluate the efficacy and tolerability of high dose sildenafil as a salvage therapy for patients refractory to the maximum recommended dose of sildenafil. Fifty four fully evaluated patients with chronic erectile failure ED who had previously failed to respond to a home trial of sildenafil mg with erections suitable for sexual intercourse were studied. Each man was treated at home with sildenafil at escalating doses of up to mg until either maximal response or intolerable adverse effects occurred.

   
8.3

Agathe (taken for 1 to 5 years) 03.08.2018

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The Cmax and AUC of tizanidine increased by 7-fold and fold, respectively. In vitro studies of cytochrome P isoenzymes using human liver microsomes indicate that neither tizanidine nor the major metabolites are likely to affect the metabolism of other drugs metabolized by cytochrome P isoenzymes. No specific pharmacokinetic study was conducted to investigate interaction between oral contraceptives and Zanaflex.

   
9.0

Christoph (taken for 3 to 5 years) 18.06.2018

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Because of the risk of adverse renal effects see Cautions: Renal Effects, diluted solutions of acyclovir should not be infused over a period less than 1 hour. When oral acyclovir is used for the treatment of mucocutaneous HSV infections in immunocompromised adults, including those infected with human immunodeficiency virus HIV, some clinicians recommend a dosage of mg every 4 hours while awake 5 times daily for days.

For the treatment of these infections in immunocompromised children, the American Academy of Pediatrics AAP recommends an oral dosage of 1 g daily given in divided doses for days.

   
9.3

Wolfram (taken for 3 to 4 years) 10.04.2018

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