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The original antibacterial sulfonamides are synthetic nonantibiotic antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase DHPS, an enzyme involved in folate synthesis. Humans, in contrast to bacteria, acquire folate vitamin B 9 through the diet. Sulfonamides are used to treat allergies and cough, as well as antifungal and antimalarial functions.
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