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What is montelukast, and how does it work mechanism of action? Montelukast is an oral leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis hay fever. Leukotrienes are a group of naturally occurring chemicals in the body that promote inflammation in asthma and seasonal allergic rhinitis and in other diseases in which inflammation is important such as allergy. It is the binding to other cells that stimulates the cells to cause inflammation. Montelukast works in a manner similar to zafirlukast Accolate, blocking the binding of some leukotrienes to the cells that cause inflammation. Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4, two enzymes in the liver that are important in breaking down and eliminating many drugs.

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