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It is a peripherally selective dopamine D 2 receptor antagonist and was developed by Janssen Pharmaceutica. There is some evidence that domperidone has antiemetic activity. Gastroparesis is a medical condition characterised by delayed emptying of the stomach when there is no mechanical gastric outlet obstruction. Its cause is most commonly idiopathic, a diabetic complication or a result of abdominal surgery. The condition causes nausea, vomiting, fullness after eating, early satiety feeling full before the meal is finished, abdominal pain and bloating. Domperidone may be useful in diabetic and idiopathic gastroparesis. However, increased rate of gastric emptying induced by drugs like domperidone does not always correlate equate well with relief of symptoms. Parkinson's disease is a chronic neurological condition where a decrease in dopamine in the brain leads to rigidity stiffness of movement, tremor and other symptoms and signs. Poor gastrointestinal function, nausea and vomiting is a major problem for people with Parkinson's disease because most medications used to treat Parkinson's disease are given by mouth.
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