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Each vial contains, as the active ingredient, cefuroxime sodium for injection equivalent to mg of cefuroxime. Vials containing an off-white to slightly yellow sterile powder for solution for injection or infusion. Cefuroxime sodium for injection is indicated for the treatment of infections listed below in adults and children, including neonates from birth see sections 4. In the treatment and prevention of infections in which it is very likely that anaerobic organisms will be encountered, cefuroxime should be administered with additional appropriate antibacterial agents. Consideration should be given to official guidance on the appropriate use of antibacterial agents. Surgical prophylaxis for gastrointestinal, gynaecological surgery including caesarean section and orthopaedic operations. This may be supplemented with two mg doses intramuscularly after 8 hours and 16 hours. Cefuroxime is primarily excreted by the kidneys. Therefore, as with all such antibiotics, in patients with markedly impaired renal function it is recommended that the dosage of Cefuroxime should be reduced to compensate for its slower excretion.
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Zinnat is indicated for the treatment of the infections listed below in adults and children from the age of 3 months see sections 4. Consideration should be given to official guidance on the appropriate use of antibacterial agents. Children aged two years or older with otitis media or, where appropriate, with more severe infections. Cefuroxime axetil tablets and cefuroxime axetil granules for oral suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis see section 5. In infants from the age of 3 months and children with a body mass of less than 40 kg, it may be preferable to adjust dosage according to weight or age. The safety and efficacy of cefuroxime axetil in patients with renal failure have not been established.
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