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Two simple and sensitive kinetic methods were developed for the determination of ribavirin in bulk and in its pharmaceutical preparations using alkaline potassium permanganate as an oxidizing agent. The methods are based upon a kinetic investigation of the oxidation reaction of the drug at room temperature for fixed times of 20 and 30 minutes. In the first method, the absorbance of the colored manganate ion was measured at nm, while in second method the reduction in the absorbance of permanganate was measured at nm. Ribavirin 1-beta-D-ribofuranosyl-1H-1, 2, 4 thiazolecarboxamine Fig. It inhibits the replication of a wide range of RNA and DNA viruses, including orthomyxo-, paramyxo-, arena-, bunya-, herpes-, adeno-, pox- and retro viruses.
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