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Tacrolimus Prograf, Astellas Pharma US is a potent immunosuppressive medication that is recommended as a first-line agent in many renal transplantation protocols. To gain marketing approval for a generic drug, a manufacturer first must prove bioequivalence in the rate and extent of absorption. Despite FDA standards, many clinicians have been reluctant to substitute generic drugs for branded products, especially those with a narrow range between efficacy and safety e. Data for the clinical use of generic tacrolimus are limited. In vitro studies comparing various non-U. In this series, the drop in tacrolimus trough concentrations did not cause https://www.teladoc.com acute graft rejection or alter surrogate markers for liver and kidney function. Because laws regarding generic substitution vary among states, this model does not simulate a real-world scenario in which a patient, upon filling a prescription at a retail pharmacy, might be switched to a generic bioequivalent because of copayment policies or because of the availability of another product without the knowledge of the treating clinician. In addition, the two U. Accord Healthcare, Dr. Reddy Labs, Panacea Biotec Ltd.
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