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Clarinex: 0. Desloratadine, a major active metabolite of loratadine, is a long-acting tricyclic antihistamine with selective peripheral histamine H 1 receptor antagonistic activity. Hepatic to active metabolite, 3-hydroxydesloratadine specific enzymes not identified ; subsequently undergoes glucuronidation. Decreased in slow metabolizers of desloratadine. Not expected to affect or be affected by medications metabolized by CYP with normal doses.

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