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The optimal dose and timing of 5-HT 3 antagonist administration for prophylaxis against postoperative nausea and vomiting PONV remains controversial. Although 5-HT 3 antagonists seem to be most effective when administered near the end of surgery, there are no data on the comparative efficacy or costs associated with the 5-HT 3 antagonists dolasetron and ondansetron when administered at the end of the operation.

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