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Duloxetine hydrochloride is used for the acute and maintenance treatment of major depressive disorder in adults. Efficacy of duloxetine for the acute treatment of major depression has principally been established by 4 double-blind, placebo-controlled studies of weeks' duration in outpatient settings in adults. Efficacy of duloxetine for the maintenance treatment of major depressive disorder has been established in a randomized, placebo-controlled relapse prevention study in which adult outpatients who met DSM-IV criteria for major depressive disorder initially received duloxetine 60 mg once daily in a week, open-label acute phase.
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It is used to treat depression and generalized anxiety disorder. For depression and anxiety, duloxetine works by affecting the balance of chemicals in the brain and other parts of the body.
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