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Phenytoin has a narrow therapeutic window, and is highly protein-bound. However, unbound phenytoin is the active portion it crosses the blood-brain barrier. This calculator helps estimate the equivalent active amount of phenytoin based on typical lab values. Helps avoid under- or over-dosing in patients with renal failure or low albumin. Please fill out required fields. Concomitant use of valproic acid and some other drugs displaces phenytoin from plasma proteins and can lead to erratic levels.
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Free unbound carbamazepine levels may be useful in cases where protein binding may be altered e. Carbamazepine,11 epoxide levels may be helpful when signs of toxicity are present but carbamazepine levels are normal.
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Take gabapentin at least 2 hours after antacids. Serious Dermatologic Reactions Advise patients of the early signs and symptoms of severe cutaneous adverse reactions and to report any occurrence immediately to a physician see Warnings and Precautions 5!
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Phenytoin injection is contraindicated in patients with sinus bradycardia, sino-atrial block, second or third degree AV block, and Adams-Stokes syndrome because of the effects of the drug on ventricular automaticity. Intravenous phenytoin should not be used in patients with other cardiac conduction abnormalities e.
Erna (taken for 2 to 6 years) 15.05.2017
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Proven to help treat tonic-clonic grand mal and psychomotor temporal lobe seizures, and to prevent and treat seizures that happen during or after brain surgery. Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that will not stop status epilepticus.
Victoria (taken for 1 to 6 years) 23.02.2018
46 users found this comment helpful.
It works by slowing down impulses in the brain that cause seizures. Dilantin is used to control seizures.
Maximilian (taken for 3 to 5 years) 04.12.2019
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