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Etodolac is a nonsteroidal anti-inflammatory drug with selective cyclooxygenase-2 inhibition to treat pain and inflammation associated with osteoarthritis in humans and dogs. The plasma concentrations of etodolac were detected using liquid chromatography-tandem mass spectrometry. Pharmacokinetic analysis was conducted using the noncompartmental method and modeling approaches. A two-compartment pharmacokinetic model with first-order absorption and elimination rate constants was successfully explained for the pharmacokinetic aspects of etodolac in dogs. Search in: This Journal Anywhere. Advanced search.

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Objective —To evaluate in vivo activity of carprofen, deracoxib, and etodolac on prostanoid production in several target tissues in dogs with chronic osteoarthritis. Procedure —Each dog received carprofen, deracoxib, or etodolac for 10 days with a to day washout period between treatments. On days 0, 3, and 10, prostaglandin PG E 2 concentrations were measured in lipopolysaccharide-stimulated blood, synovial fluid, and gastric mucosal biopsy specimens; PGE 1 concentrations were measured in gastric mucosal biopsy specimens; and thromboxane B 2 TXB 2 was evaluated in blood. Results —Carprofen and deracoxib significantly suppressed PGE 2 concentrations in blood at days 3 and 10, compared with baseline, whereas etodolac did not. None of the drugs significantly suppressed TXB 2 concentrations in blood or gastric PGE 1 synthesis at any time point.

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Kurt (taken for 3 to 7 years) 30.10.2019

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Use lowest effective dose for shortest duration. May give mg once daily for long-term use.

   
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Johannes (taken for 3 to 5 years) 21.07.2017

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It is used to reduce swelling and to treat mild to moderate pain. This medicine may be used to treat osteoarthritis or rheumatoid arthritis. Take this medicine by mouth with a full glass of water.

   
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Tobias (taken for 3 to 6 years) 10.08.2019

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Before you take etodolac, tell your doctor if you have ever had an allergic reaction to any other anti-inflammatory painkiller. Etodolac is prescribed to ease pain and reduce inflammation for people with rheumatic conditions such as osteoarthritis and rheumatoid arthritis. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

   
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Edeltraud (taken for 3 to 5 years) 24.11.2017

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