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Common side effects include headache, dizziness, feeling tired, and intestinal upset. Gemfibrozil was patented in and came into medical use in The exact mechanism of action of gemfibrozil is unknown; however, several theories exist regarding the very low density lipoprotein VLDL effect; it can inhibit lipolysis and decrease subsequent hepatic fatty acid uptake as well as inhibit hepatic secretion of VLDL; together these actions decrease serum VLDL levels and increase HDL-cholesterol; the mechanism behind HDL elevation is currently unknown. Gemfibrozil increases the activity of extrahepatic lipoprotein lipase LL, thereby increasing lipoprotein triglyceride lipolysis. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL. It is also detected as environmental persistent micropollutant in aquifers and in groundwaters in karstic areas. From Wikipedia, the free encyclopedia. US : C Risk not ruled out.
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Myositic syndrome, cholelithiasis, GI disturbances, rash, headache, blood dyscrasias, myalgia. Impotence, painful extremities, blurred vision; pruritus, urticaria; impotence; dizziness; cholestatic jaundice. Potentially Fatal: Bone marrow hypoplasia; intracranial haemorrhage; nephrotoxicity; peripheral neuritis. Co-admin with repaglinide may increase serum levels of repaglinide. May enhance effects of oral anticoagulants. May also increase the plasma concentrations of ciclosporin and associated nephrotoxicity when used concurrently.
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Lopid Gemfibrozil is a cholesterol-regulating medication used to lower the levels of triglycerides in people with pancreatitis. Gemfibrozil helps reduce very high blood cholesterol levels in people who have not responded to diet and exercise.
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Gemfibrozil is a fibrate and it is commonly used to lower cholesterol and triglyceride in combination with statins for hyperlipidemia to prevent cardiovascular disease Wierzbicki et al. From: Transporters in Drug Discovery and Development,
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Lopid gemfibrozil is a lipid regulating agent used to treat very high cholesterol and triglyceride levels in people with pancreatitis, and is also used to lower the risk of stroke, heart attack, or other heart complications in people with high cholesterol and triglycerides who have not been helped by other treatments. Common side effects of Lopid include. Lopid may infrequently cause gallstones and liver problems.
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