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There was a significant reduction in body mass index, but the reduction in waist circumference was not significant. Minimum duration was 12 weeks. Primary outcomes were body weight, waist circumference and body mass index BMI. Open label studies were excluded. Olanzapine dose ranged from 5mg to 20mg. Control groups used olanzapine plus placebo. All studies included patients with schizophrenia, two studies included only schizophrenia patients, one study included with patients with schizoaffective disorder and one study included patients with bipolar disorder. Methodological quality was assessed using the five-point Jadad scale of randomisation, double-blinding and description of withdrawals and drop-outs. There were too few studies to assess publication bias.

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