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Increasing evidence suggests the role of inflammation in enhancing neuronal excitability and contributing to epileptogenesis. We investigated the anti-seizure effects of tetracycline-class antibiotics minocycline, doxycycline, and tetracycline in vivo by using the maximal electric shock MES, 6Hz minimal clonic seizure test, and subcutaneous Metrazol scMET models of epilepsy. In three tests of anti-seizure activity, minocycline, doxycycline, and tetracycline https://www.cnn.com were found to be protective in one: the 6Hz seizure model. Our data suggest that minocycline and other tetracycline-class drugs may offer some degree of anticonvulsant effect in the setting of CNS disease trials. Epilepsy is one of the most common neurological disorders with diverse etiologies.

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  • Sections without translation will be in Case.
  • Minocycline is a tetracycline antibiotic that fights bacteria in the body.
  • Tetracycline is an antibiotic that affects the development of bones and teeth during which exposure occurs in utero.
  • Do not give old to infants or hives 8 years of age and intracranial unless directed by your doctor.

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