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A randomised double-blind trial comparing arimidex alone with nolvadex alone with arimidex and nolvadex in combination, as adjuvant treatment in post-menopausal women with breast cancer. Group A: Arimidex anstrozole 1 mg plus Nolvadex tamoxifen placebo both daily for 5 years or until recurrence 2. Group B: Arimidex 1 mg plus, both daily for 5 years or until recurrence 3. Group C: Arimidex placebo plus, both daily for 5 years or until recurrence. Patients must have completed primary surgery and chemotherapy if given, and are candidates to receive hormonal adjuvant therapy 3.
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Psychiatric disorders: Insomnia, dream abnormalities, depression,confusion and hallucinations. Cardiac disorders: Oedema, palpitations, cardiac failure and congestive heart failure have been reported in association with NSAID treatment. Clinical trial and epidemiological data suggest that use of coxibs and some NSAIDs particularly at high doses and in long term treatment may be associated with a small increased risk of arterial thrombotic events for example myocardial infarction or stroke see section 4. Hepatobiliary disorders: abnormal liver function, hepatitis including some fatalities and jaundice. Nervous system disorders: convulsions, dizziness, headache, lightheadedness, drowsiness, inability to concentrate and cognitive dysfunction, retrobulbar optic neuritis, paraesthesia, exacerbation of parkinson's disease, reports of aseptic meningitis especially in patients with existing auto-immune disorders, such as systemic lupus https://www.marcs.com erythematosus, mixed connective tissue disease, with symptoms such as stiff neck, headache, nausea, vomiting, fever and disorientation see section 4. Haematological : Thrombocytopenia, eosinophilia, leucopenia, neutropenia, agranulocytosis, decreased platelet aggregation, prolonged bleeding time, aplastic anaemia and haemolytic anaemia.
Estrogens plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. The Women's Health Initiative WHI estrogen plus progestin substudy reported increased risks of deep vein thrombosis, pulmonary embolism, stroke and myocardial infarction in postmenopausal women 50 to 79 years of age during 5. It is unknown whether this finding applies to younger postmenopausal women. The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer. Progestins with estrogens should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. Progesterone has a molecular weight of They are also indicated for use in secondary amenorrhea.
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