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The required daily dose ranges from mg to 3 g. Therapy should be initiated with a low dose of mg or mg daily. In order to minimise the gastro-intestinal side-effects the daily dose should be divided and taken with or after meals. Generally, daily doses of mg to mg are sufficient. If diabetic control is incomplete a cautious increase in dosage to a maximum of 2 to 3g daily is justified. No additional benefit can usually be achieved by use of doses exceeding 3g daily. Once control has been achieved it may be possible to reduce the daily dose.

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Not enough data were available at that time to determine the relative risk of death or of death from heart disease. The discomfort can often be avoided by beginning at a low dose 1. In healthy individuals, this slight excess is cleared by other mechanisms including uptake by unimpaired kidneys, and no significant elevation in blood levels of lactate occurs. Extracorporeal treatments are recommended in severe overdoses. Chromatographic techniques are commonly employed. Anticholinergic drugs reduce gastric motility, prolonging the time drugs spend in the gastrointestinal tract.

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However, the final decision will always be the prescriber's. Controlling high blood sugar will help prevent kidney damage, nerve problems, blindness, loss of limbs, and sexual problems.

   
9.3

Brigitte (taken for 1 to 5 years) 07.08.2016

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The most common side-effects are feeling sick, diarrhoea and tummy abdominal pain. These symptoms usually pass after the first few days of treatment.

   
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David (taken for 3 to 7 years) 05.01.2017

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Treatment of type 2 diabetes mellitus,particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability.

   
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Konrad (taken for 2 to 6 years) 02.03.2019

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