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Rockville, MD Voice. DOI : PDE3 inhibition in platelets and vascular smooth muscle cells VSMC was expected to provide an antiplatelet effect and vasodilation. Recent preclinical studies have demonstrated that CLZ also possesses the ability to inhibit adenosine uptake by various cells, a property that distinguishes CLZ from other PDE3 inhibitors, such as milrinone. Despite its remarkable antiplatelet properties, CLZ is not generally considered an antithrombotic agent in Western countries, perhaps due to the bulk of its antithrombotic preclinical and clinical development being conducted in Japan. Keywords: cilostazol, pletaal, adenosine, antithrombotic, intermittent claudication, stroke, and restenosis. Volume 9, Issue 28, Journal Home.

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Pletoz Cilostazol is both an anti-platelet medication and a vasodilator. It is prescribed to treat blood circulation problems affecting the legs commonly referred to as intermittent claudication.

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Given the benefits of sympatholysis in the surgical period and the risks associated with clonidine withdrawal, patients who have been taking this drug should have it administered orally the day surgery and resumed as soon as possible postoperatively. The most effective treatment of postoperative clonidine withdrawal is resumption of clonidine.


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