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This case study is presented as an example for classical on-target drug repurposing and the challenges that such a project can face. Acetylcholine is a key neurotransmitter that regulates many functions in the CNS, as well as in other body organs, through the cholinergic system. However, its known actions might allow repurposing toward even more applications not only in psychiatry and neurology but also in eye medicine and even in immunology. This article summarizes the claims, the evidence and the potential of galantamine beyond its currently approved uses. There is anecdotal evidence that some European neuropsychiatrists used Nivalin off-label to treat cognitive and emotional impairments after traumatic brain injury. Evidently, the supply bottleneck had to be removed to enable development, which could ultimately require galantamine to be reliably available in the low metric ton scale on a yearly basis.
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Galantamine is a member of the cholinesterase inhibitors drug class and is commonly used for Alzheimer's Disease. Prices are for cash paying customers only and are not valid with insurance plans.
Renate (taken for 3 to 5 years) 17.10.2017
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Bozyczko-Coyne, M. Galantamine 4, a naturally occurring plant tertiary alkaloid, is a reversible AChE inhibitor that is a weak positive allosteric modular of nAChRs. The proposed presynaptic actions of galantamine may also lead to the modulation of glutamate, serotonin, and norepinephrine release, all of which are affected in AD.
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