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Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury 9. It may also be caused by musculoskeletal injury 5. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition. Initially approved by the FDA in, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm Label. A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Tizanidine is used alone or in conjunction with other standard therapies e. In these patients, tizanidine decreases the number and severity of spasms, alleviates clonus, and improves mobility to a greater extent than does placebo. Some evidence from comparative studies suggests that tizanidine may https://www.cvs.com produce muscle weakness less frequently than other antispastic agents e. The manufacturer states that because of its short duration of effect, tizanidine should be reserved for those daily activities and times when relief of spasticity is most important. Efficacy for the management of spasticity has been demonstrated in 2 placebo-controlled, randomized studies in patients with multiple sclerosis or spinal cord injury. In these studies, patients years of age received initial tizanidine hydrochloride dosages of 2 or 4 mg daily, which were titrated according to response and tolerance to a maximum of 36 mg in up to 3 divided doses daily over a 3-week period.

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Common side effects include dry mouth, sleepiness, weakness, and dizziness. Tizanidine was approved for medical use in the United States in Tizanidine has been found to be as effective as other antispasmodic drugs and is more tolerable than baclofen and. Side effects include dizziness, drowsiness, weakness, nervousness, hallucinations, depression, vomiting, dry mouth, constipation, diarrhea, stomach pain, heartburn, increased muscle spasms, back pain, rash, sweating, and a tingling sensation in the arms, legs, hands, and feet. Concomitant use of tizanidine and moderate or potent CYP1A2 inhibitors such as zileuton, certain antiarrhythmics amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, aciclovir, ticlopidine and oral contraceptives is contraindicated.

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Gottfried (taken for 2 to 7 years) 29.01.2020

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Zanaflex tizanidine is a member of the skeletal muscle relaxants drug class and is commonly used for Cluster Headaches and Muscle Spasm. Prices are for cash paying customers only and are not valid with insurance plans. Important : When there is a range of pricing, consumers should normally expect to pay the lower price.

   
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