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Twelve patients required escalation of the Advagraf dose by 1. For the whole group the daily tacrolimus dose was increased from 0. Tacrolimus is a calcineurin inhibitor CNI with proven efficacy in the prevention of acute renal allograft rejection. The objective of this study was to investigate the Advagraf dose requirement in relation to the baseline Prograf dose to maintain the target trough blood tacrolimus level in stable Chinese renal transplant recipients converting from Prograf to Advagraf, with or without concomitant diltiazem treatment. Clinical parameters including body weight, blood pressure, clinical events and drug doses were recorded. Laboratory parameters including h post-dose trough tacrolimus level, serum creatinine, liver enzymes, and uric acid level were recorded at week 12, 0, 2, 4, 8,
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