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CNS-active drugs produce specific electroencephalographic changes and the concentration-effect relationship of antipsychotics may be elucidated by adopting electroencephalography EEG as an effect measurement tool. The purpose of the present study was to determine the concentration-effect relationship of risperidone by assessing the EEG effect after oral administrations of single dose risperidone in healthy young males. Nine healthy male volunteers received a 1 mg single oral dose of risperidone according to a placebo controlled crossover design. Plasma levels of risperidone and its active metabolite 9-hydroxyrisperidone were measured by radioimmunoassay. The difference in the absolute power in the delta frequency band for the F3 lead between risperidone and placebo was used as a drug effect parameter. The hysteresis loop was observed in the plot of plasma concentration of risperidone or sum of risperidone and 9-hydroxyrisperidone Cp versus EEG effect for each subject.


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Rosa (taken for 3 to 7 years) 07.05.2016

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Syphilis is a sexually transmitted disease STD caused by a spiral-shaped type of bacteria known as a spirochete. There are three stages of syphilis with distinct symptoms.


Adolf (taken for 2 to 5 years) 28.05.2017

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This drug is distributed to body tissues shortly after administration. It is known to cross the placenta. The plasma contains high levels of salicylate, as well as tissues such as spinal, peritoneal and synovial fluids, saliva and milk.


Nikolaus (taken for 3 to 5 years) 20.12.2019

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