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We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension PH after correction of valvular heart disease VHD. The Kaplan—Meier estimates for survival without admission due to HF were 0. Changes in 6-min walk test distance, natriuretic peptides, and Doppler-derived systolic pulmonary pressure were similar in both groups. Treatment with sildenafil in patients with persistent PH after successfully corrected VHD is associated to worse clinical outcomes than placebo. Off-label usage of sildenafil for treating this source of left heart disease PH should be avoided.


Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete intercourse.


Matthias (taken for 1 to 5 years) 29.11.2018

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Melanie (taken for 2 to 6 years) 22.05.2019

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Leonhard (taken for 1 to 5 years) 20.05.2018

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