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At lower doses, the adverse effects of venlafaxine, including nausea, vomiting, gastrointestinal adverse effects, and sexual dysfunction, are similar to that of other SSRIs, while at higher doses it becomes similar to that of norepinephrine reuptake inhibitors. In a previous study by Mbaya et al. Polymorphism of the genes CYP2D6 and CYP2C19 which are involved in the metabolism of venlafaxine may change the pharmacokinetics of the agent and cause the adverse side effects at different drug levels.

   
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