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Tizanidine HCl is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in water and methanol; solubility in water decreases as the pH increases. Zanaflex is a central alphaadrenergic agonist indicated for the management of spasticity. Zanaflex Capsules and Zanaflex tablets are bioequivalent to each other under fasting conditions more than 3 hours after a meal, but not under fed conditions within 30 minutes of a meal. These changes may result in increased adverse events, or delayed or more rapid onset of activity, depending upon the nature of the switch.

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Comments:

Therapy with conventional tizanidine tablets is effective in the relief of spasticity, but it has a short half-life, resulting in it having to be administered three or four times daily. The modified release capsules have retard characteristics which allow the drug to be given as a once-daily dosage. Mild, transient muscular weakness was the most common effect, but it did not require termination of treatment.

   
6.5

Agathe (taken for 1 to 7 years) 18.11.2018

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Tizanidine is a central acting muscle relaxant medicine that primarily affects the central nervous system, escpecially the spinal cord. Its antispasmodic activity is due to the agonist effect on central presynaptic alpha 2 - adrenergic receptors. It mainly acts at the level of the spinal cord.

   
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Marie (taken for 2 to 7 years) 17.12.2019

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You should not take tizanidine if you are also taking fluvoxamine Luvox or ciprofloxacin Cipro. Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities.

   
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Gerhard (taken for 2 to 7 years) 08.11.2017

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Zanaflex tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses pain sensations that are sent to your brain.

   
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Gabriel (taken for 1 to 5 years) 31.07.2017

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